GENE-56. DEPLETION OF 5-HYDROXYMETHYLCYTOSINE IN AGGRESSIVE G-CIMP SUBTYPE

5-hydroxymethylcytosine (5hmC) is an oxidation product of 5-methylcytosine, a reaction potentially mediated by the Tet family of enzymes. Levels of 5hmC were reported to be lower in glioblastoma and because gliomas carrying an IDH1/2 mutation (high or low grade) manifest a CpG island methylator phen...

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發表在:Neuro Oncol
Main Authors: Sabedot, Thais Sarraf, Poisson, Laila, deCarvalho, Ana C, Noushmehr, Houtan
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692938/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.428
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