CSIG-31. PRE-CLINICAL STUDY AND CLINICAL DEVELOPMENT OF AXL-TARGETING THERAPY FOR RECURRENT GLIOBLASTOMA

Glioblastoma (GBM) is a lethal disease without effective therapies. Previously we reported that the TAM receptor tyrosine kinase family member AXL is upregulated in mesenchymal GBM and its knockdown induces apoptosis of mesenchymal but not proneural glioma sphere cultures (GSCs). In this study, we r...

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Publicat a:Neuro Oncol
Autors principals: Sadahiro, Hirokazu, Kang, Kyung-Don, Nabors, Burt, Norian, Lyse, Hambardzumyan, Dolores, Dasgupta, Biplab, Nakada, Mitsutoshi, Nakano, Ichiro
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692918/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.225
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