ANGI-12. IDENTIFICATION OF A NOVEL TYROSINE KINASE/INTEGRIN COMPLEX THAT DRIVES BRAIN METASTASES

INTRODUCTION: Brain metastases, the most common brain tumors, confer a poor prognosis. Studies have suggested roles for β1-integrin and c-Met, but the mechanisms remain unelucidated. We hypothesized that a c-Met/b1integrin complex drives breast cancer cells to metastasize to the brain and elsewhere....

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Publicat a:Neuro Oncol
Autors principals: Jahangiri, Arman, Sidorov, Maxim, Nguyen, Alan, Yagnik, Garima, Han, Sung Won, Mascharak, Smita, De Lay, Michael, Wagner, Jeffrey, Castro, Brandyn, Imber, Brandon, Lu, Kan, Bergers, Gabriele, Weiss, William, Aghi, Manish K
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692766/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.090
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