PATH-52. TIME-VARYING EFFECT OF MGMT METHYLATION LEVEL ON SURVIVAL OF GLIOBLASTOMA MULTIFORME

Standard treatment for patients with glioblastoma multiforme (GBM) consists of surgery, radiotherapy and concomitant and adjuvant treatment with the alkylating agent temozolomide (TMZ). The repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) removes the alkyl groups thereby preventing DNA da...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Dahlrot, Rikke H, Larsen, Pia V, Boldt, Henning, Kreutzfeldt, Melissa S, Hjelmborg, Jacob v B, Hansen, Steinbjørn, Kristensen, Bjarne W
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692757/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.741
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