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EXTH-35. STEADY STATE BRAIN EXTRACELLULAR FLUID AND PLASMA PHARMACOKINETICS OF LETROZOLE IN SPRAGUE DAWLEY RATS: GENDER DIFFERENCES AND PROJECTIONS FOR TUMORAL DRUG LEVELS
Our recent studies indicate that aromatase, a cytochrome P450 (CYP) enzyme (CYP19A1), which catalyzes the conversion of androgens to estrogens, may be a novel druggable target for the treatment of high-grade gliomas (HGG). Additionally, letrozole, a potent aromatase inhibitor, exhibited marked activ...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692731/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.327 |
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