EXTH-35. STEADY STATE BRAIN EXTRACELLULAR FLUID AND PLASMA PHARMACOKINETICS OF LETROZOLE IN SPRAGUE DAWLEY RATS: GENDER DIFFERENCES AND PROJECTIONS FOR TUMORAL DRUG LEVELS

Our recent studies indicate that aromatase, a cytochrome P450 (CYP) enzyme (CYP19A1), which catalyzes the conversion of androgens to estrogens, may be a novel druggable target for the treatment of high-grade gliomas (HGG). Additionally, letrozole, a potent aromatase inhibitor, exhibited marked activ...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Arora, Priyanka, Huff, Courtney, Dave, Nimita, Gudelsky, Gary, Desai, Pankaj
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
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Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692731/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.327
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