EXTH-68. RECURRENT XENOGRAFT TUMORS UPREGULATE EGFR AFTER LENTIVIRAL VECTOR MEDIATED SUICIDE GENE THERAPY FOR GLIOBLASTOMA, BUT ARE RESISTANT TO COMBINATORIAL TREATMENT WITH ERLOTINIB

BACKGROUND: Lentiviral vector mediated herpes simplex virus thymidine kinase (HSV-Tk)/ ganciclovir (GCV) therapy is a very promising therapeutic option for the treatment of glioblastoma (GBM). Although this therapy leads to complete remission of GBM in an orthotopic PDX model, recurrent tumors are o...

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Vydáno v:Neuro Oncol
Hlavní autoři: Hossain, Jubayer, Ystaas, Lars, Latif, Abdul, Joseph, Justin, Talasila, Krishna, Ninzima, Sandra, Riecken, Kristoffer, Fehse, Boris, Bjerkvig, Rolf, Miletic, Hrvoje
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692650/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.360
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