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ATIM-17. EARLY RESULTS OF A MULTICENTER PHASE I AND OPEN-LABEL, RANDOMIZED PHASE II STUDY TESTING THE TOXICITIES AND EFFICACY OF MK-3475 (PEMBROLIZUMAB) IN COMBINATION WITH MRI-GUIDED LASER INTERSTITIAL THERMAL THERAPY (LITT) IN RECURRENT MALIGNANT GLIOMAS
BACKGROUND: LITT was recently demonstrated to induce temporary blood-brain barrier disruption, possibly allowing bilateral trafficking of tumor neoantigens and immune cells to induce glioma-specific immune activation - a phenomenon akin to in situ tumor vaccination. We hypothesize that combining LIT...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692634/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.112 |
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