EXTH-50. DEVELOPMENT OF INVESTIGATOR INITIATED CLINICAL TRIAL OF TERT-TARGETING THERAPY USING ERIBULIN MESYLATE IN PATIENTS WITH RECURRENT GLIOBLASTOMA

Despite of recent intense investigations, no effective molecular targeting therapy has been successfully developed in patients with glioblastomas (GBMs). Approximately 60–80% of GBM harbor mutations in the promoter region of telomerase reverse transcriptase (TERT), which leads to its upregulation. I...

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Publicado no:Neuro Oncol
Main Authors: Takahashi, Masamichi, Miki, Shunichiro, Fukuoka, Kohei, Maida, Yoshiko, Hayashi, Mitsuhiro, Hamada, Akinobu, Nishikawa, Ryo, Nagane, Motoo, Maruyama, Takashi, Mukasa, Akitake, Arakawa, Yoshiki, Arita, Hideyuki, Kitamura, Natsuko, Yonemori, Kan, Tamura, Kenji, Masutomi, Kenkichi, Narita, Yoshitaka, Ichimura, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692632/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.342
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