PDCT-19. A SAFETY STUDY OF VEMURAFENIB, AN ORAL INHIBITOR OF BRAF(V600E), IN CHILDREN WITH RECURRENT/REFRACTORY BRAF(V600E) MUTANT BRAIN TUMORS: PNOC-002

BACKGROUND: Vemurafenib is an orally available, selective ATP-competitive inhibitor of BRAF-V600E kinase, approved in adult metastatic melanoma patients with the V600E mutation. This study was designed to determine the recommended phase 2 dose (RP2D) in patients < 18yrs with BRAF-V600E mutant bra...

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Publicado en:Neuro Oncol
Autores principales: Nicolaides, Theo, Nazemi, Kellie, Crawford, John, Kilburn, Lindsay, Minturn, Jane, Gajjar, Amar, Gauvain, Karen, Leary, Sarah, Dhall, Girish, Aboian, Mariam, Robinson, Giles, Molinaro, Annette, Mueller, Sabine, Prados, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Abstracts
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692489/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.761
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