SCDT-06. QUANTIFIABLE LEVELS OF THE TRANSGENE, CYTOSINE DEAMINASE, IN TUMOR SAMPLES FOLLOWING INTRAVENOUS DELIVERY OF TOCA 511 IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA

Toca 511 (vocimagene amiretroprepvec) is an investigational, conditionally lytic, retroviral replicating vector that encodes an optimized yeast cytosine deaminase (CD) gene. The CD gene converts the prodrug, Toca FC (investigational, extended-release 5-fluorocytosine), into the chemotherapeutic, 5-F...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Walbert, Tobias, Bota, Danilella, Vogelbaum, Michael, Kalkanis, Steven, Liau, Linda, Mikkelsen, Tom, Gruber, Harry, Shorr, Jolene, Rodriguez-Aguirre, Maria, Ostertag, Derek, Mitchell, Leah, Jolly, Doug, Cloughesy, Timothy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Abstracts
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692436/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1089
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