CSIG-24. ANDROGEN RECEPTOR IS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA

Androgen receptor (AR) gene is mapped to Xq11-12. It functions as a steroid-hormone-activated-transcription-factor. AR splice variants lacking the Ligand-Binding-Domain (LBD), such as AR-V7/AR3, which arise primarily through exon skipping and cryptic exon inclusion, are activated in a ligand-indepen...

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Publicado en:Neuro Oncol
Main Authors: Zalsman, Nomi, Canello, Tamar, Ovadia, Haim, Charbit, Hanna, Zelikovitch, Bracha, Mordechai, Anat, Fellig, Yakov, Rabani, Stav, Shahar, Tal, Lossos, Alexander, Lavon, Iris
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692375/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.218
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