TMIC-48. REGULATION OF THE PROTEASE ADAM17 BY EXTRACELLULAR SIGNALS DRIVES PRO-TUMORAL PROGRAMS IN GLIOBLASTOMA CELLS AND THEIR MICROENVIRONMENT.

The cell-surface metalloprotease ADAM17/TACE regulates multiple signaling cascades, such as Notch and NFkB, which are critical for glioblastoma (GBM) growth and invasion. This enzyme is tonically inhibited by the extracellular matrix (ECM)-associated protein TIMP3, but signals that release ADAM17 in...

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Vydáno v:Neuro Oncol
Hlavní autoři: Nandhu, Mohan Sobhana, Bhaskaran, Vivek, Hu, Bin, Viapiano, Mariano
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692266/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1036
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