Cargando...
TMIC-48. REGULATION OF THE PROTEASE ADAM17 BY EXTRACELLULAR SIGNALS DRIVES PRO-TUMORAL PROGRAMS IN GLIOBLASTOMA CELLS AND THEIR MICROENVIRONMENT.
The cell-surface metalloprotease ADAM17/TACE regulates multiple signaling cascades, such as Notch and NFkB, which are critical for glioblastoma (GBM) growth and invasion. This enzyme is tonically inhibited by the extracellular matrix (ECM)-associated protein TIMP3, but signals that release ADAM17 in...
Gardado en:
| Publicado en: | Neuro Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692266/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1036 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|