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TMIC-48. REGULATION OF THE PROTEASE ADAM17 BY EXTRACELLULAR SIGNALS DRIVES PRO-TUMORAL PROGRAMS IN GLIOBLASTOMA CELLS AND THEIR MICROENVIRONMENT.
The cell-surface metalloprotease ADAM17/TACE regulates multiple signaling cascades, such as Notch and NFkB, which are critical for glioblastoma (GBM) growth and invasion. This enzyme is tonically inhibited by the extracellular matrix (ECM)-associated protein TIMP3, but signals that release ADAM17 in...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692266/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1036 |
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