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GENE-15. CHARACTERIZATION OF DIFFERENTIAL 5-HYDROXYMETHYLCYTOSINE IN IDH1 MUTANT VERSUS IDH1 WILD-TYPE HIGH-GRADE GLIOMAS
Glioblastoma demonstrates significant epigenetic dysregulation, with subgroup differences highlighted by the Glioma CpG-island methylator phenotype (G-CIMP) seen in IDH1 mutant tumors. 5-hydroxymethylcytosine (5hmC) has been implicated in IDH1 wild-type tumors (Johnson et al, Nat Commun Nov 2016), h...
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| Izdano u: | Neuro Oncol |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692219/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.389 |
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