GENE-15. CHARACTERIZATION OF DIFFERENTIAL 5-HYDROXYMETHYLCYTOSINE IN IDH1 MUTANT VERSUS IDH1 WILD-TYPE HIGH-GRADE GLIOMAS

Glioblastoma demonstrates significant epigenetic dysregulation, with subgroup differences highlighted by the Glioma CpG-island methylator phenotype (G-CIMP) seen in IDH1 mutant tumors. 5-hydroxymethylcytosine (5hmC) has been implicated in IDH1 wild-type tumors (Johnson et al, Nat Commun Nov 2016), h...

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Publicado en:Neuro Oncol
Main Authors: Glowacka, Wioletta, Jain, Harshika, Okura, Makiko, Maimaitiming, Abulizi, Yasin, Mamatjan, Farooq, Hamza, Aldape, Kenneth, Kongkham, Paul
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692219/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.389
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