PDTM-14. THE DISTRIBUTION, CLEARANCE AND TOXICITY OF PANOBINOSTAT ADMINISTERED TO JUVENILE RAT AND PIG BRAINSTEM BY CONVECTION ENHANCED DELIVERY

The pan-histone deacetylase inhibitor panobinostat has preclinical efficacy against DIPG and the oral formulation has entered a phase one clinical trial. However, panobinostat does not cross the blood brain barrier in humans. Convection enhanced delivery (CED) is a novel neurosurgical drug delivery...

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Published in:Neuro Oncol
Main Authors: Singleton, Will, Bienemann, Alison, Woolley, Max, Johnson, David, Lewis, Owen, Wyatt, Marcella, Damment, Steve, Boulter, Lisa, Killick-Cole, Clare, Asby, Daniel, Gill, Steven
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692209/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.778
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