ACTR-02. DCC-2618, A NOVEL pan-KIT AND PDGFRa KINASE SWITCH CONTROL INHIBITOR, SHOWS ENCOURAGING SIGNAL IN A PATIENT (PT) WITH GLIOBLASTOMA (GBM)

BACKGROUND: Non-clinical data suggest that PDGFRa plays an important role in the development and progression of human gliomas. To date, few PDGFRa inhibitors with CNS activity have been available. DCC-2618 was designed to potently inhibit the broadest range of mutations (mut) in KIT & PDGFRa kin...

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Publicado no:Neuro Oncol
Main Authors: de Groot, John, George, Suzanne, Razak, Albiruni, Gordon, Michael, Janku, Filip, Ligon, Keith, Wen, Patrick, Friedlander, Sharon, Flynn, Daniel, Kaufman, Michael, Pitman, Jama, Ruiz-Soto, Rodrigo, Smith, Bryan, Westwood, Deborah, Rosen, Oliver, Reardon, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691962/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.002
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