Hypomethylation of HOXA4 promoter is common in Silver-Russell syndrome and growth restriction and associates with stature in healthy children

Silver-Russell syndrome (SRS) is a growth retardation syndrome in which loss of methylation on chromosome 11p15 (11p15 LOM) and maternal uniparental disomy for chromosome 7 [UPD(7)mat] explain 20–60% and 10% of the syndrome, respectively. To search for a molecular cause for the remaining SRS cases,...

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Publicado no:Sci Rep
Main Authors: Muurinen, Mari, Hannula-Jouppi, Katariina, Reinius, Lovisa E., Söderhäll, Cilla, Merid, Simon Kebede, Bergström, Anna, Melén, Erik, Pershagen, Göran, Lipsanen-Nyman, Marita, Greco, Dario, Kere, Juha
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691194/
https://ncbi.nlm.nih.gov/pubmed/29146936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16070-5
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