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A Single Nucleotide Polymorphism of p27(Kip1) Associated with Human Vein Graft Failure Affects Growth of Human Venous Adventitial Cells not Smooth Muscle Cells

INTRODUCTION: p27(Kip1) is a cell-cycle inhibitor whose −838C>A single nucleotide polymorphism (rs36228499; hereafter called p27 SNP) has been associated with the clinical failure of peripheral vein grafts, but the functional effects of this SNP have not been demonstrated. METHODS: Human saphenou...

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Detalhes bibliográficos
Publicado no:J Vasc Surg
Main Authors: Kenagy, Richard D, Kikuchi, Shinsuke, Chen, Lihua, Wijelath, Errol S, Stergachis, Andrew B, Stamatoyannopoulos, John, Tang, Gale L, Clowes, Alexander W, Sobel, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690896/
https://ncbi.nlm.nih.gov/pubmed/28526559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvs.2016.12.113
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