Mitochondrial genomic backgrounds affect nuclear DNA methylation and gene expression

Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse strain(s) - designated Mitochondrial Nuclear Exchange (MNX) –...

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Udgivet i:Cancer Res
Main Authors: Vivian, Carolyn J., Brinker, Amanda E., Graw, Stefan, Koestler, Devin C., Legendre, Christophe, Gooden, Gerald C., Salhia, Bodour, Welch, Danny R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690839/
https://ncbi.nlm.nih.gov/pubmed/28663334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1473
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