Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma

Malignant mesothelioma (MM) is an aggressive malignancy, highly resistant to current medical and surgical therapies, whose tumor cells characteristically show a high level of aneuploidy and genomic instability. We tested our hypothesis that targeting chromosomal instability in MM would improve respo...

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Veröffentlicht in:Oncogene
Hauptverfasser: Szymiczek, Agata, Carbone, Michele, Pastorino, Sandra, Napolitano, Andrea, Tanji, Mika, Minaai, Michael, Pagano, Ian, Mason, Jacqueline M., Pass, Harvey I., Bray, Mark R., Mak, Tak W., Yang, Haining
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690838/
https://ncbi.nlm.nih.gov/pubmed/28759042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.266
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