High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma

We used a custom-made comparative genomic hybridization array (aCGH; average probe interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy number loss throughout the 3p21 region (10.7 Mb) that harbors 251 genes, including BRCA1 (breast cancer 1)-associated protein 1 (BAP1...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yoshikawa, Yoshie, Emi, Mitsuru, Hashimoto-Tamaoki, Tomoko, Ohmuraya, Masaki, Sato, Ayuko, Tsujimura, Tohru, Hasegawa, Seiki, Nakano, Takashi, Nasu, Masaki, Pastorino, Sandra, Szymiczek, Agata, Bononi, Angela, Tanji, Mika, Pagano, Ian, Gaudino, Giovanni, Napolitano, Andrea, Goparaju, Chandra, Pass, Harvey I., Yang, Haining, Carbone, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127333/
https://ncbi.nlm.nih.gov/pubmed/27834213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612074113
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