High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma

We used a custom-made comparative genomic hybridization array (aCGH; average probe interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy number loss throughout the 3p21 region (10.7 Mb) that harbors 251 genes, including BRCA1 (breast cancer 1)-associated protein 1 (BAP1...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yoshikawa, Yoshie, Emi, Mitsuru, Hashimoto-Tamaoki, Tomoko, Ohmuraya, Masaki, Sato, Ayuko, Tsujimura, Tohru, Hasegawa, Seiki, Nakano, Takashi, Nasu, Masaki, Pastorino, Sandra, Szymiczek, Agata, Bononi, Angela, Tanji, Mika, Pagano, Ian, Gaudino, Giovanni, Napolitano, Andrea, Goparaju, Chandra, Pass, Harvey I., Yang, Haining, Carbone, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127333/
https://ncbi.nlm.nih.gov/pubmed/27834213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612074113
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