Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extrem...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Mackelprang, Romel D., Bamshad, Michael J., Chong, Jessica X., Hou, Xuanlin, Buckingham, Kati J., Shively, Kathryn, deBruyn, Guy, Mugo, Nelly R., Mullins, James I., McElrath, M. Juliana, Baeten, Jared M., Celum, Connie, Emond, Mary J., Lingappa, Jairam R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690691/
https://ncbi.nlm.nih.gov/pubmed/29108000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006703
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