Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which genes modulate phenotypic variability, what their relationship i...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Katsanos, Dimitris, Koneru, Sneha L., Mestek Boukhibar, Lamia, Gritti, Nicola, Ghose, Ritobrata, Appleford, Peter J., Doitsidou, Maria, Woollard, Alison, van Zon, Jeroen S., Poole, Richard J., Barkoulas, Michalis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690688/
https://ncbi.nlm.nih.gov/pubmed/29108019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2002429
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