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Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil

New promising avenues for the pharmacological treatment of skeletal and heart muscle diseases rely on direct sarcomeric modulators, which are molecules that can directly bind to sarcomeric proteins and either inhibit or enhance their activity. A recent breakthrough has been the discovery of the myos...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Hashem, Shaima, Tiberti, Matteo, Fornili, Arianna
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690683/
https://ncbi.nlm.nih.gov/pubmed/29108014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005826
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