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Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil

New promising avenues for the pharmacological treatment of skeletal and heart muscle diseases rely on direct sarcomeric modulators, which are molecules that can directly bind to sarcomeric proteins and either inhibit or enhance their activity. A recent breakthrough has been the discovery of the myos...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Comput Biol
Prif Awduron: Hashem, Shaima, Tiberti, Matteo, Fornili, Arianna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690683/
https://ncbi.nlm.nih.gov/pubmed/29108014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005826
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