Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

Dedifferentiation of acini to duct-like cells occurs during the physiologic damage response in the pancreas, but this process can be co-opted by oncogenic Kras to drive carcinogenesis. Myeloid cells infiltrate the pancreas during the onset of pancreatic cancer, and promote carcinogenesis. Here, we s...

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Udgivet i:eLife
Main Authors: Zhang, Yaqing, Yan, Wei, Mathew, Esha, Kane, Kevin T, Brannon, Arthur, Adoumie, Maeva, Vinta, Alekya, Crawford, Howard C, Pasca di Magliano, Marina
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690281/
https://ncbi.nlm.nih.gov/pubmed/28980940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27388
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