MDM4 genetic variants predict HPV16-positive tumors of patients with squamous cell carcinoma of the oropharynx

The increasing incidence of squamous cell carcinoma of the oropharynx (SCCOP) is majorly attributed to the human papillomavirus (HPV) infection. Both HPV and MDM4 play a critical role in inhibition of p53 activity, thus affecting HPV tumor status of SCCOP. Three polymorphisms in MDM4 were genotyped...

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Vydáno v:Oncotarget
Hlavní autoři: Lu, Zhongming, Zhang, Hua, Tao, Ye, Li, Xiangping, Li, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689719/
https://ncbi.nlm.nih.gov/pubmed/29156829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21414
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