Uncoupling TORC2 from AGC kinases inhibits tumour growth

Mammalian target of rapamycin (mTOR) is a central regulator of growth and metabolism. mTOR resides in two distinct multi-protein complexes – mTORC1 and mTORC2 – with distinct upstream regulators and downstream targets. While it is possible to specifically inhibit mTORC1 with rapamycin, or inhibit bo...

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Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Cameron, Angus J.M., Veeriah, Selvaraju, Marshall, Jacqueline J.T., Murray, Elizabeth R., Larijani, Banafshé, Parker, Peter J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2017
Aiheet:
Priority Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689566/
https://ncbi.nlm.nih.gov/pubmed/29156676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20086
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