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Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms
Myeloproliferative neoplasm (MPN) is a hematologic malignancy characterized by the clonal outgrowth of hematopoietic cells with a somatically acquired mutation most commonly in JAK2 (JAK2(V)(617)(F)). This mutation endows upon myeloid progenitors cytokine independent growth and consequently leads to...
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| Vydáno v: | J Theor Biol |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5689470/ https://ncbi.nlm.nih.gov/pubmed/28501635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2017.05.012 |
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