Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy

BACKGROUND: Patients with congenital diaphragmatic hernia (CDH) have structural and functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to respond to standard vasodilator therapy targeting the major vasoactive pathways, causing a high morbidity and mortality. W...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Mous, Daphne S., Buscop-van Kempen, Marjon J., Wijnen, Rene M. H., Tibboel, Dick, Rottier, Robbert J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688796/
https://ncbi.nlm.nih.gov/pubmed/29115963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0670-2
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