Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

BACKGROUND: Forkhead box O3A (FOXOA3) and apolipoprotein E (APOE) are arguably the strongest gene candidates to influence human exceptional longevity (EL, i.e., being a centenarian), but inconsistency exists among cohorts. Epistasis, defined as the effect of one locus being dependent on the presence...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Fuku, Noriyuki, Díaz-Peña, Roberto, Arai, Yasumichi, Abe, Yukiko, Zempo, Hirofumi, Naito, Hisashi, Murakami, Haruka, Miyachi, Motohiko, Spuch, Carlos, Serra-Rexach, José A., Emanuele, Enzo, Hirose, Nobuyoshi, Lucia, Alejandro
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688477/
https://ncbi.nlm.nih.gov/pubmed/29143599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4194-4
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