FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian....

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Vydáno v:Age (Dordr)
Hlavní autoři: Sanchis-Gomar, Fabian, Garatachea, Nuria, He, Zi-hong, Pareja-Galeano, Helios, Fuku, Noriyuki, Tian, Ye, Arai, Yasumichi, Abe, Yukiko, Murakami, Haruka, Miyachi, Motohiko, Yvert, Thomas, Santiago, Catalina, Venturini, Letizia, Fiuza-Luces, Carmen, Santos-Lozano, Alejandro, Rodríguez-Romo, Gabriel, Ricevuti, Giovanni, Hirose, Nobuyoshi, Emanuele, Enzo, Lucia, Alejandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245403/
https://ncbi.nlm.nih.gov/pubmed/25427998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-014-9733-1
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