Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells

Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8(−/−) or Dicer(−/–) embryonic stem cells (ESCs), contain no mature miRNA and cannot differentiate into somatic cells. How miRNA deficiency causes differentiation defects remains poorly understood. Here, we report that miR-3...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Liu, Zhong, Zhang, Cheng, Skamagki, Maria, Khodadadi-Jamayran, Alireza, Zhang, Wei, Kong, Dexin, Chang, Chia-Wei, Feng, Jingyang, Han, Xiaosi, Townes, Tim M., Li, Hu, Kim, Kitai, Zhao, Rui
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688240/
https://ncbi.nlm.nih.gov/pubmed/29141234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.10.006
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