DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation

Receptor activator of NF-kB ligand (RANKL) generates intracellular reactive oxygen species (ROS), which increase RANKL-mediated signaling in osteoclast (OC) precursor bone marrow macrophages (BMMs). Here we show that a ROS scavenging protein DJ-1 negatively regulates RANKL-driven OC differentiation,...

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Publicado en:Nat Commun
Main Authors: Kim, Hyuk Soon, Nam, Seung Taek, Mun, Se Hwan, Lee, Sun-Kyeong, Kim, Hyun Woo, Park, Young Hwan, Kim, Bokyung, Won, Kyung-Jong, Kim, Hae-Rim, Park, Yeong-Min, Kim, Hyung Sik, Beaven, Michael A., Kim, Young Mi, Choi, Wahn Soo
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688089/
https://ncbi.nlm.nih.gov/pubmed/29142196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01527-y
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