HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

While beta-amyloid (Aβ), a classic hallmark of Alzheimer’s disease (AD) and dementia, has long been known to be elevated in the human immunodeficiency virus type 1 (HIV-1)-infected brain, why and how Aβ is produced, along with its contribution to HIV-associated neurocognitive disorder (HAND) remains...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chai, Qingqing, Jovasevic, Vladimir, Malikov, Viacheslav, Sabo, Yosef, Morham, Scott, Walsh, Derek, Naghavi, Mojgan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688069/
https://ncbi.nlm.nih.gov/pubmed/29142315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01795-8
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