CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer

In this study, we used a bioinformatic approach to identify genes whose expression is dysregulated in human prostate cancers. One of the most dramatically downregulated genes identified encodes CYP27A1, an enzyme involved in regulating cellular cholesterol homeostasis. Importantly, lower CYP27A1 tra...

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Publicado en:Cancer Res
Main Authors: Alfaqih, Mahmoud A., Nelson, Erik R., Liu, Wen, Safi, Rachid, Jasper, Jeffery S., Macias, Everardo, Geradts, Joseph, Thompson, J. Will, Dubois, Laura G., Freeman, Michael R., Chang, Ching-yi, Chi, Jen-Tsan, McDonnell, Donald P., Freedland, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687884/
https://ncbi.nlm.nih.gov/pubmed/28130224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2738
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