A null mutation in SERPINE1 protects against biological aging in humans

Plasminogen activator inhibitor–1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology and prolong...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Khan, Sadiya S., Shah, Sanjiv J., Klyachko, Ekaterina, Baldridge, Abigail S., Eren, Mesut, Place, Aaron T., Aviv, Abraham, Puterman, Eli, Lloyd-Jones, Donald M., Heiman, Meadow, Miyata, Toshio, Gupta, Sweta, Shapiro, Amy D., Vaughan, Douglas E.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687852/
https://ncbi.nlm.nih.gov/pubmed/29152572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao1617
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