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Statistical considerations in the choice of endpoint for drug use disorder trials

BACKGROUND: To date, the US Food and Drug Administration (FDA) requires drug use disorder trials developing new medications to use abstinence, a clinically meaningful endpoint, as the primary outcome. Although abstinence is the gold standard, only a relatively small percentage of participants in dru...

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Detalhes bibliográficos
Publicado no:Drug Alcohol Depend
Main Authors: Fitzmaurice, Garrett M., Lipsitz, Stuart R., Weiss, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687831/
https://ncbi.nlm.nih.gov/pubmed/29102827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2017.09.031
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