Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia is Characterized by Distinct Genomic Subsets with Varying Outcomes

Acute Megakaryoblastic Leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) in which cells morphologically resemble abnormal megakaryoblasts. While rare in adults, AMKL accounts for 4–15% of newly diagnosed childhood AML(1–3). AMKL in patients without Down syndrome (non-DS-AMKL) is frequentl...

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Publicado no:Nat Genet
Main Authors: de Rooij, Jasmijn D.E., Branstetter, Cristyn, Ma, Jing, Li, Yongjin, Walsh, Michael P., Cheng, Jinjun, Obulkasim, Askar, Dang, Jinjun, Easton, John, Verboon, Lonneke J., Mulder, Heather L., Zimmermann, Martin, Koss, Cary, Gupta, Pankaj, Edmonson, Michael, Rusch, Michael, Lim, Joshua Yew Suang, Reinhardt, Katarina, Pigazzi, Martina, Song, Guangchun, Yeoh, Allen Eng Juh, Shih, Lee-Yung, Liang, Der-Cherng, Halene, Stephanie, Krause, Diane S., Zhang, Jinghui, Downing, James R., Locatelli, Franco, Reinhardt, Dirk, van den Heuvel-Eibrink, Marry M., Zwaan, C. Michel, Fornerod, Maarten, Gruber, Tanja A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687824/
https://ncbi.nlm.nih.gov/pubmed/28112737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3772
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