High-affinity human PD-L1 variants attenuate the suppression of T cell activation

The activated T cells can be suppressed by programed death-1 (PD-1) axis through low affinity interaction between PD-1 and PD-ligand 1 (PD-L1) in solution or on antigen presenting cells. In clinic, the concentration of soluble PD-L1 in peripheral blood negatively correlates with cancer prognosis. Ho...

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Vydáno v:Oncotarget
Hlavní autoři: Liang, Zhaoduan, Tian, Ye, Cai, Wenxuan, Weng, Zhiming, Li, Yanyan, Zhang, Huanling, Bao, Yifeng, Li, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper: Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687611/
https://ncbi.nlm.nih.gov/pubmed/29179441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21729
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