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High-affinity human PD-L1 variants attenuate the suppression of T cell activation
The activated T cells can be suppressed by programed death-1 (PD-1) axis through low affinity interaction between PD-1 and PD-ligand 1 (PD-L1) in solution or on antigen presenting cells. In clinic, the concentration of soluble PD-L1 in peripheral blood negatively correlates with cancer prognosis. Ho...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687611/ https://ncbi.nlm.nih.gov/pubmed/29179441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21729 |
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