Crosstalk of LKB1‐regulated and PTEN‐regulated signals in liver morphogenesis and tumor development in mice

Liver kinase B 1 (LKB1 or STK11) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) are two tumor suppressors that regulate the mammalian target of rapamycin signaling pathway. Deletion studies show that loss of either Lkb1 (Lkb(+/–)) or Pten (Pten(loxP/loxP); Alb‐Cre(+)) leads to...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Jia, Chengyou, Medina, Vivian, Liu, Chenchang, He, Lina, Qian, Daohai, Tu, Taojian, Okamoto, Curtis T., Stiles, Bangyan L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687583/
https://ncbi.nlm.nih.gov/pubmed/29152604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1027
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