Vector Order Determines Protection against Pathogenic Simian Immunodeficiency Virus Infection in a Triple-Component Vaccine by Balancing CD4(+) and CD8(+) T-Cell Responses

An effective AIDS vaccine should elicit strong humoral and cellular immune responses while maintaining low levels of CD4(+) T-cell activation to avoid the generation of target cells for viral infection. The present study investigated two prime-boost regimens, both starting vaccination with single-cy...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sauermann, Ulrike, Radaelli, Antonia, Stolte-Leeb, Nicole, Raue, Katharina, Bissa, Massimiliano, Zanotto, Carlo, Krawczak, Michael, Tenbusch, Matthias, Überla, Klaus, Keele, Brandon F., De Giuli Morghen, Carlo, Sopper, Sieghart, Stahl-Hennig, Christiane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686736/
https://ncbi.nlm.nih.gov/pubmed/28904195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01120-17
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