Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys

BACKGROUND: The cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) are innate cellular factors that inhibit replication of a number of viruses, including HIV-1. Since antiviral activity of APOBEC3 has been mainly confirmed by in vitro data, we examined their role for disease progression in the SI...

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Detalhes bibliográficos
Main Authors: Mußil, Bianka, Sauermann, Ulrike, Motzkus, Dirk, Stahl-Hennig, Christiane, Sopper, Sieghart
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192745/
https://ncbi.nlm.nih.gov/pubmed/21955401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-77
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