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Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly

The dynamic SCF (Skp1–cullin1–F-box protein) assembly is controlled by cycles of cullin neddylation/deneddylation based on the deneddylation activity of the COP9 signalosome (CSN) and global sequestration of cullins by CAND1. However, acceptance of this prediction was hampered by the results of rece...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Liu, Qingqing, Zhou, Yike, Tang, Ruiqi, Wang, Xuehong, Hu, Qiwen, Wang, Ying, He, Qun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686579/
https://ncbi.nlm.nih.gov/pubmed/28923850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00109-17
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