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Structural basis for a reciprocal regulation between SCF and CSN
SCF (Skp1-Cul1-Fboxes) E3 ligases are activated by ligation to the ubiquitin-like protein Nedd8, which is reversed by the deneddylating Cop9 Signalosome (CSN). However, CSN also promotes SCF substrate turnover through unknown mechanisms. Through biochemical and electron microscopy analyses, we deter...
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| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3703508/ https://ncbi.nlm.nih.gov/pubmed/22959436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.08.019 |
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