Structural basis for a reciprocal regulation between SCF and CSN

SCF (Skp1-Cul1-Fboxes) E3 ligases are activated by ligation to the ubiquitin-like protein Nedd8, which is reversed by the deneddylating Cop9 Signalosome (CSN). However, CSN also promotes SCF substrate turnover through unknown mechanisms. Through biochemical and electron microscopy analyses, we deter...

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Bibliografski detalji
Glavni autori: Enchev, Radoslav I., Scott, Daniel C., da Fonseca, Paula C. A., Schreiber, Anne, Monda, Julie K., Schulman, Brenda A., Peter, Matthias, Morris, Edward P.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703508/
https://ncbi.nlm.nih.gov/pubmed/22959436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.08.019
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