miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

Activation of mammalian target of rapamycin (mTOR) signaling pathway is associated with poor prognosis of epithelial ovarian cancer. The TSC1-TSC2 complex is a critical negative regulator of mTOR signaling. Here, we demonstrated that TSC1 was frequently downregulated in high-grade serous ovarian car...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Wang, Yuqiong, Zhang, Xiyu, Tang, Wei, Lin, Zhenghong, Xu, Limei, Dong, Ruifen, Li, Yinuo, Li, Jieyin, Zhang, Zaixin, Li, Xiangzhi, Zhao, Ling, Wei, Jian-Jun, Shao, Changshun, Kong, Beihua, Liu, Zhaojian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686346/
https://ncbi.nlm.nih.gov/pubmed/28800130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.129
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