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Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape

In crystallopathies, crystals or crystalline particles of environmental and metabolic origin deposit within tissues, induce inflammation, injury and cell death and eventually lead to organ-failure. The NLRP3-inflammasome is involved in mediating crystalline particles-induced inflammation, but pathwa...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Honarpisheh, Mohsen, Foresto-Neto, Orestes, Desai, Jyaysi, Steiger, Stefanie, Gómez, Lidia Anguiano, Popper, Bastian, Boor, Peter, Anders, Hans-Joachim, Mulay, Shrikant R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686194/
https://ncbi.nlm.nih.gov/pubmed/29138474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15804-9
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