JAK2(V617I) results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model

A germline JAK2(V617I) point mutation results in hereditary thrombocytosis and shares some phenotypic features with myeloproliferative neoplasm, a hematologic malignancy associated with a somatically acquired JAK2(V617F) mutation. We established a mouse transduction-transplantation model of JAK2(V61...

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Udgivet i:Exp Hematol
Main Authors: Brooks, Stefan A., Luty, Samuel B., Lai, Hew Yeng, Morse, Sarah J., Nguyen, Thanh Kim, Royer, Lacey R., Agarwal, Anupriya, Druker, Brian J., Fleischman, Angela G.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685804/
https://ncbi.nlm.nih.gov/pubmed/26458983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2015.09.006
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